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As we get older, our skin has less firmness, elasticity and volume.1 You may not notice your body’s collagen production slowing down, but have you noticed the effects?
HArmonyCa™ is designed to rejuvenate skin by helping to restore what gets lost – in just one treatment. 1-5,*,†,‡
* Results from a prospective and non-randomised interventional study where HArmonyCa™ was injected in the preauricular region of 15 women. The primary endpoint were the volumetric changes at Day 180. Secondary endpoints included changes in facial tension vectors, time to filler tissue integration and safety profile.2
† Ultrasound and elastography examinations were performed. When compared to baseline, an increase in density, viscoelasticity, and firmness of the tissue was observed at 60 days and then confirmed at 90 days after treatment. At 180 days after treatment an increase in collagen in the treated areas was confirmed.2
‡ Vectra® H2 (Canfield Scientific, Inc.) was used to assess volumetric changes, with a median (interquartile-range) volume increased by 2.1 (1.9–2.3) cc and 2.1 (1.8–2.2) cc in the right-and left-side, respectively, p<0.0001 each at Day 180.2
1. Reilly DM and Lozano J. Plast Aesthet Res. 2021;8:2.
2. Urdiales-Gálvez F et al. J Cosmet Dermatol. 2023;00:1–12.
3. Swift A et al. Aesthet Surg J. 2020;sjaa339.
4. Kahn DM, Shaw RB. Facial Plast Surg. 2010;26:350–355.
5. Coleman SR, Grover R. Aesthet Surg J. 2006;26:S4-S9.
Everyone’s talking about dual-effect injectables.
HArmonyCaTM is one such treatment: it combines two components that work in harmony.1,3
One is HA (Hyaluronic acid) to immediately restore lost volume. The other is CaHA (Calcium hydroxyapatite) to support the body’s own collagen production. The desired result? Skin may appear firmer, tighter and with a lifting effect that may last up to 6 months . 1,2,*,†,**
* Results from a prospective and non-randomised interventional study where HArmonyCa™ was injected in the preauricular region of 15 women. The primary endpoint were the volumetric changes at Day 180. Secondary endpoints included changes in facial tension vectors, time to filler tissue integration and safety profile.2
† Ultrasound and elastography examinations were performed. When compared to baseline, an increase in density, viscoelasticity, and firmness of the tissue was observed at 60 days and then confirmed at 90 days after treatment. At 180 days after treatment an increase in collagen in the treated areas was confirmed.2
** Vectra® H2 (Canfield Scientific, Inc.) was used to assess skin lift and tightening by measuring the changes in facial tension vector (FTV) at 60, 90, and 180 days after treatment. As compared to pre-treatment values, FTV significantly increased at all timepoints with a median (interquartile-range) increased by 2.2 (1.6– 2.2) mm and 2.0 (1.7–2.2) mm in the right and left side, respectively p < 0.0001 each, 180 days after treatment.2
1.Allergan Aesthetics. HArmonyCa™ Lidocaine IFU. M032 V01. 2021.
2. Urdiales-Gálvez F et al. J Cosmet Dermatol. 2023;00:1–12.
3. Allergan Aesthetics. Data on File. HArmonyCa™ Manufacturing. October 2023. REF-98172
Practitioners tell us patient concerns include2*:
• cheek lines
• loss of contour in lower face
• sagginess in lower face
• lack of skin firmness
• skin looking old
The issue is this: as you age, thinning skin and loss of elasticity occur over time due to the gradual loss of hyaluronic acid, collagen and elastin.1
HArmonyCa™ offers a different way to facial harmony … it can help encourage the sustained production of collagen in skin as early as 1 week after treatment!3**
Why not ask your practitioner how HArmonyCa™ is designed to address multiple signs of ageing in one treatment, restoring firmness, elasticity and lost volume? 1,4-6, §,†,‡
*Individual treatment results may vary.2 **Results from a pre-clinical animal study of HArmonyCa™ with lidocaine, with results demonstrated over 8 weeks.3
§ Results from a prospective and non-randomised interventional study where HArmonyCa™ was injected in the preauricular region of 15 women. The primary endpoint were the volumetric changes at Day 180. Secondary endpoints included changes in facial tension vectors, time to filler tissue integration and safety profile.4
† Ultrasound and elastography examinations were performed. When compared to baseline, an increase in density, viscoelasticity, and firmness of the tissue was observed at 60 days and then confirmed at 90 days after treatment. At 180 days after treatment an increase in collagen in the treated areas was confirmed.4
‡ Vectra® H2 (Canfield Scientific, Inc.) was used to assess volumetric changes, with a median (interquartile-range) volume increased by 2.1 (1.9–2.3) cc and 2.1 (1.8–2.2) cc in the right-and left-side, respectively, p<0.0001 each at Day 180.4
1. Swift A et al. Aesthet Surg J. 2021;41(10):1107–19.
2. HArmonyCa Lidocaine - Train-the-trainer meeting 2022 Reported outputs. REF-114077 and REF-114078
3. Allergan Aesthetics. Data on File. HArmonyCa™ Lidocaine INT-HAR-2150040. Collagen stimulation. July 2021.
4. Urdiales-Gálvez F, et al. J Cosmet Dermatol. 2023. doi: 10.1111/jocd.15706
5. Kahn DM, Shaw RB. Facial Plast Surg. 2010;26:350–355.
6. Coleman SR, Grover R. Aesthet Surg J. 2006;26:S4-S9.
Any injectable treatment may carry the risk of side effects, which is why it’s important to discuss everything with your practitioner to make an informed decision. You can also ask them for after-care advice.
Common side effects with HArmonyCa™ may include redness, swelling, pain, tenderness and itching around the injection area.1 However, these are generally mild and usually resolve within 1–2 days and any swelling within a week.1 You can find out more in our FAQs section.
1. Allergan Aesthetics. HArmonyCa™ Lidocaine IFU. M032 V01. 2021.
Your practitioner should discuss everything in detail and create a bespoke treatment plan.1 You may also want to ask if HArmonyCa™ could fit into your wider aesthetic treatment plan for the results you’re after? 2,3,§§,¶¶
Before you undergo any treatment, your healthcare practitioner will go through your history, treatment goals and the region you wish to be treated for your desired outcome.2,4
HArmonyCa™ contains lidocaine to help make your treatment more comfortable.2 Your healthcare practitioner will assess your needs and, if necessary, apply the appropriate form of anaesthetic. They may also apply ice to the injection site to reduce swelling.2
Following treatment some of the side effects you may experience include redness, swelling and itching in the treated areas. 2
You should be able to return to work and resume most daily activities on the same day as your treatment with HArmonyCa™ though individual treatment results may vary. 2
*The safety and efficacy of HArmonyCa™ has not been evaluated in patients treated with other filling implants.
§§ Based on a survey of N=70 physicians when asked ""In your experience, do you combine other technologies to your treatment plans with HArmonyCa™?3
¶¶ The safety of HArmonyCa™ Lidocaine injectable implant with concomitant dermal therapies such as epilation, UV irradiation, or laser, mechanical or chemical peeling procedures has not been evaluated in controlled clinical trials.2
UK-HAR-230133 | Date of prep: September 2024